Instability of Pathogenicity Islands in Uropathogenic Escherichia coli 536
نویسندگان
چکیده
منابع مشابه
The pathogenicity islands (PAIs) of the uropathogenic Escherichia coli strain 536: island probing of PAI II536.
Pathogenicity islands (PAIs) represent distinct pieces of DNA that are present in the genomes of pathogenic bacteria but absent from the genomes of related nonpathogenic strains. They carry (often more than one) virulence genes and are linked to transfer RNA (tRNA) loci. In addition, they carry mobility genes and direct repeats at their ends and are often unstable [1]. The first PAIs have been ...
متن کاملGenetic structure and distribution of four pathogenicity islands (PAI I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536.
For the uropathogenic Escherichia coli strain 536 (O6:K15:H31), the DNA sequences of three pathogenicity islands (PAIs) (PAI I(536) to PAI III(536)) and their flanking regions (about 270 kb) were determined to further characterize the virulence potential of this strain. PAI I(536) to PAI III(536) exhibit features typical of PAIs, such as (i) association with tRNA-encoding genes; (ii) G+C conten...
متن کاملS-Fimbria-encoding determinant sfa(I) is located on pathogenicity island III(536) of uropathogenic Escherichia coli strain 536.
The sfa(I) determinant encoding the S-fimbrial adhesin of uropathogenic Escherichia coli strains was found to be located on a pathogenicity island of uropathogenic E. coli strain 536. This pathogenicity island, designated PAI III(536), is located at 5.6 min of the E. coli chromosome and covers a region of at least 37 kb between the tRNA locus thrW and yagU. As far as it has been determined, PAI...
متن کاملTwo pathogenicity islands in uropathogenic Escherichia coli J96: cosmid cloning and sample sequencing.
Many of the virulence genes of pathogenic strains of Escherichia coli are carried in large multigene chromosomal segments called pathogenicity islands (PAIs) that are absent from normal fecal and laboratory K-12 strains of this bacterium. We are studying PAIs in order to better understand factors that govern virulence and to assess how such DNA segments are gained or lost during evolution. The ...
متن کاملLarge, unstable inserts in the chromosome affect virulence properties of uropathogenic Escherichia coli O6 strain 536.
The hemolytic, uropathogenic Escherichia coli 536 (O6:K15:H31) contains two inserts in its chromosome (insert I and insert II), both of which carried hly genes, were rather unstable, and were deleted spontaneously with a frequency of 10(-3) to 10(-4). These inserts were not found in the chromosome of two nonhemolytic E. coli strains, whereas the chromosomal sequences adjacent to these inserts a...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2004
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.186.10.3086-3096.2004